Methotrexate is administered once weekly as a single dose or in divided doses given over a 24-hour period. To reduce the incidence of major toxic effects, methotrexate should never be given in daily doses.

Methotrexate can be administered as an injection in your muscle or orally. If you can find a doctor to do an injection of methotrexate, you should get 50 mg/m2 of methotrexate intramuscularly followed by 800 micro gm of intravaginal misoprostol 3-7 days after the methotrexate. You can also use the metrotrexate orally (75 mg). Most methotrextate tablets contain 5 or 10 mg that means you will have to swallow quite a lot of tablets.